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KMID : 0370220070510060490
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Yakhak Hoeji
2007 Volume.51 No. 6 p.490 ~ p.494
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Process Development for Large Scale Synthesis of TRH
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Kim Dong-Hyeon
Pritam Thapa
Radha Karki
Jahng Yurng-Dong
Lee Eung-Seok
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Abstract
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TRH (thyrotropin-releasing hormone) was chemically synthesized utilizing solution phase peptide chemistry for the process development of large scaled synthesis. All the synthetic steps performed in relatively mild conditions, higher yields, easier preparations, minimum racemizations, and separation and purification by recrystallizations.
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KEYWORD
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TRH (thyrotropin-releasing hormone), process development, peptide synthesis
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